Purpose: Peripheral artery disease (PAD) disproportionately affects patients from culturally and linguistically diverse (CALD) backgrounds. This study aimed to assess the association between CALD status and cardiovascular risks in patients with PAD, and whether patients’ quality of life differs. Methods: This cross-sectional analysis included patients with PAD from the TEAM-PAD trial, who were recruited from Concord Repatriation General Hospital between August 2023 to June 2024. Participants were categorised into CALD and non-CALD groups based on country of birth, language spoken at home and need for an interpreter. Cardiovascular risks were calculated using the SMART-REACH calculator, and health-related quality of life (QOL) was assessed using the Peripheral Artery Questionnaire (PAQ) and validated QOL scales (PROMIS-29 and EQ-5D-5L). Descriptive and comparative analyses were conducted. Results:Eighty participants were recruited, with 40 (50%) from CALD backgrounds. The mean age was 71.2 years for the CALD group and 69.9 years for the non-CALD group. The CALD group had a higher prevalence of chronic kidney disease (27.5% vs. 10.0%, p = .045) and higher mean systolic blood pressure (p = .002). There was no significant difference in composite SMART-REACH cardiovascular risk scores between the groups. However, CALD patients reported significantly higher levels of depressive symptoms, fatigue, pain interference, and pain intensity. The EQ-5D-5L index was lower in the CALD group (0.684 ± 0.281 vs. 0.804 ± 0.220, p = .032), with higher levels of perceived problems in mobility, self-care, and usual activity. Conclusion: Whilst CALD populations with PAD do not exhibit higher cardiovascular risks compared to non-CALD populations, they face specific health challenges and report a lower quality of life. These findings underscore the necessity for healthcare providers to address these specific needs and incorporate cultural and linguistic considerations into PAD management.