Approximately 2 billion PIVCs are used annually globally. Unfortunately, PIVCs demonstrate a troubling failure rate that varies significantly across regions. Poorly secured PIVCs can also contribute to the development of phlebitis. Approximately 37% of patients with CRBSI (Catheter-related bloodstream infection) require prolonged antibiotic treatment, and 14% may need intensive care unit (ICU) and multiple organ failures. This review will elaborate the efficacy of tissue adhesive (TA) as a PIVC securement device to decrease the number of PIVC failures. The study review Randomised Controlled Trials (RCTs) of TA compared with another PIVC securement devices. The detailed criteria are adult or paediatric patients. The search was performed in EMBASE, MEDLINE, and EBSCO. The first study showed phlebitis were less with TA but were not statistically significant. The second RCT’s interventions were bordered polyurethane, integrated securement dressing (ISD) and ISD with TA. The result is ISD with TA had the lowest rate of failure, but phlebitis happened more in the ISD and TA than other dressings. The third RCT was compared bordered polyurethane dressing (BPU) + non-sterile foam (NSF), (ii) ISD + sterile foam (SF), or (iii) TA + NSF. The phlebitis rate was low in TA + BPU, and ISD; the CRBSI was only happened in BPU. The fourth study intervention is TA compared with standard adhesive dressing (SAD). The result showed the rate of phlebitis was smaller in TA compared with (SAD) (it was not statistically significant). Last study has found that catheter failure was lowest in the TA group. No patient was suspected of a local or CRBSI. In conclusion, from the included study TA reduce the rate of PIVC failure. Australian Commission on Safety and Quality in Health Care [ACSQHC]. (2021). Management of PIVC clinical care standard. In. Sydney: ACSQHC.