Purpose: To assess patient survival and ancillary outcomes when managed by the Pulmonary Embolus Response Team (PERT) in Cairns Hospital. Methodology: We conducted a retrospective, single-centre cohort study. Patients admitted to ICU with a diagnosis of pulmonary embolus were included, from January 1st 2022 to December 31st 2023 inclusive. Patients identified as having low-risk PEs were excluded. Primary endpoints were all-cause mortality rate and the proportion of patients undergoing catheter-directed thrombolysis/thrombectomy or IVC filter insertion. Secondary endpoints comprised patients’ discharge destination from hospital and the incidence of haemodynamic or respiratory failure. Results 37 patients were included, only one of which suffered a massive PE. The remainder presented with submassive PEs. One patient (2.7%) was risk-stratified as being high risk, one patient was intermediate low risk, and the remaining cases were intermediate high risk. Inpatient all-cause mortality rate was 5.41% (n = 2 patients). 15 patients (41%) were treated with systemic thrombolysis, 3 patients (8%) underwent catheter-directed thrombolysis, and another 3 underwent IVC filter insertion. None required intubation or ECMO. 31 patients (84%) were directly discharged home from hospital. Conclusion An established and accessible PERT Guideline expedites commencement of appropriate, life-saving treatment. It is an especially valuable resource in a regional centre, such as Cairns Hospital, due to the high proportion of IHTs from rural and remote facilities. While our reported all-cause mortality rate is superior to that described in the literature, this is confounded by a small sample size.