The advent of catheter-directed therapies for the treatment of pulmonary embolism (PE) has ushered in an era of resurgence in terms of the investigation into the true impact and effect of these new treatment modalities. This resurgence has also lead to the rapid development of multiple devices mostly focusing on lytic-free approaches widely known as mechanical thrombectomy (MT). Another important development in this new era has been the development has been the development of pulmonary embolism response teams (PERT). These teams were developed in order to have a multidisciplinary approach to PE patients including multiple medical specialties such as, but not limited to, interventional radiology (IR), interventional cardiology (IC), vascular surgery (VS), cardiothoracic surgery (CTS), pulmonology/intensive care physicians, internal medicine and hematology. It is crucial for each member of the team to have an understanding of these modalities and the data that supports their use. Mechanical thrombectomy has emerged as a promising new therapy in the treatment of PE. There are multiple key factors to developing a successful MT PE service. In our opinion, the most important factor is understanding the local hospital system and what resources are provided and how patients have been historically treated. Education of key members is also vital so that each specialty that participates in the decision making process of these patients are all aligned on the data and education of this disease process. Furthermore, developing system wide standardized treatment algorithms and patient pathways are important in order to make sure every patient is at the very least evaluated by a physician member of the PE team. The inclusion and education of hospital administration is also crucial in order to secure necessary support and funding to build and grow a successful MT PE program.