Purpose Acute pulmonary embolism (PE) is associated with an in-hospital mortality of 25% in high-risk patients. Currently, societal guidelines recommend systemic lysis for high-risk PE despite limited data and a major bleeding risk of approximately 10%. Percutaneous thrombectomy has recently been shown to be a promising treatment for intermediate/high risk patients with PE. Here, we review our firsthand experience with this new technique. Methodology A retrospective review of patients with intermediate or high-risk PE who received percutaneous thrombectomy was conducted. We recorded patient demographics, haemodynamics and pulmonary arterial pressures pre and post intervention. We also considered their peri-procedural recovery including length of hospital stay following intervention. Results We treated 34 patients with an average age of 68. Of these patients 19/34 (56%) were male. We identified that 20/34 (59%) of these patients had high risk PE while the remaining patients (14/34) had intermediate-to-high risk PE according to the European Society of Cardiology guidelines. The Lightning Flash was the most used device in 18/34 (53%) of cases. We also used Indigo CAT8, Lightning 12, Angiojet and FlowTriever. There were no procedural complications. All cause in-hospital mortality was 4/34 (12%). All patients who survived i.e. 30/34 (88%) were discharged without an oxygen requirement, with a median length of stay of 7 days post intervention. Of the 8/34 (24%) patients who underwent echocardiography pre and post procedure, the mean post-procedural reduction in pulmonary artery pressure was 9mmHg. Conclusion The results suggest that percutaneous thrombectomy is safe and effective, and should be considered in the management of patients with intermediate or high-risk PE in an attempt to improve the short-term outcomes in this patient cohort. Further work is required to determine the impact of such therapy on the longer-term sequelae of PE.