Purpose: Pulmonary embolism (PE) is a common condition with significant short and long-term morbidity and mortality. Traditionally it was treated with supportive measures, anticoagulation and systemic lytic therapy only in select cases with haemodynamic compromise. Catheter-directed thrombolysis (CDT) with or without adjunctive clot fragmentation can be used when skills and resources are available, however its effectiveness is hampered by the age of the thrombus as well as contraindications to lytics. Lytic-free suction thrombectomy with the Inari Flowtriever system has been proposed as an option for patients with either contraindications to lytic therapy or subacute and chronic thrombus. This study reports on the safety and effectiveness of the device in a cohort of patients with acute, subacute and chronic pulmonary embolism. Methodology: A prospective single-centre registry of all patients who underwent Inari Flowtriever suction thrombectomy for high and intermediate risk acute pulmonary embolism was created that included demographics, time from symptom onset until presentation, pre- and post-operative echocardiogram and CTPA, survival to discharge and complications. Results: single session lytic-free PE suction thrombectomy was performed on 12 patients with no mortality at 30-day post-operatively. Mean age was 63 years old (range 21 to 82) and 41.7% were male). 4 were high risk and 8 intermediate risk. All patients had evidence of right heart strain on echocardiogram with a mean right ventricular systolic pressure (RVSP) was 45.5mmHg preoperatively. Technical success was 100%. All patients improve right heart strain post-operatively with a mean RSVP was 22mmHg. There were no intra-operative or post-operative procedure related complications with 100% survival at 30 days. Conclusion: single session lytic -free suction thrombectomy of PE with Inari Flowtriever is safe and effective in treating pulmonary embolism even when the thrombus is chronic.