Purpose: Venous leg ulcer (VLU) is a prevalent condition treated concurrently by vascular and dermatology. It is a condition associated with significant physical, psychological, and socioeconomic burdens. The evaluation of patient reported outcomes (PROs) is an indispensable element of research in chronic wound management. Health-related quality of life outcome (HRQol) through questionnaires such as the Sheffield Preference-based Venous Ulcer questionnaire (SPVU-5D) is well validated for measuring quality of life and impact of disease in patients with VLUs. The most well-validated HRQoL tool for the assessment of quality of life in patients with dermatological conditions is the Dermatology Life Quality Index (DLQI). To date there are no studies assessing the accuracy of DLQI for VLUs. The aim of this study is to compare the performance of DLQI to SPVU-5D in patients with VLUs. Method: A single center prospective study including all patients with VLUs between January 2024 – January 2025. Diagnosis of venous incompetency is based on clinical history, examination, and radiological findings. Ulcers of other etiology were excluded. Both DLQI and SUPVU-5D questionnaires completed at baseline and 12 week follow up. Primary outcome measured were performance of DLQI as a HRQol tool in terms of construct validity, responsiveness, and internal consistency. Results: 60 patients included to date. Median age was 76. Baseline characteristics recorded. Statistical analysis showed internal consistency of Cronbach’s alpha at 0.75. Pearson’s correlations showed r=0.6 moderate correlation for construct validation. Student T test was calculated for assessment of responsiveness. Conclusion: DLQI shows non-inferiority in comparison to SPVU-5D as an HRQoL tool for VLUs in terms of responsiveness, construct validity, and internal consistency. This provides valuable information to clinicians to evaluate the current quality of existing HrQol for VLUs.