Acute lower limb ischemia (ALI) is a vascular emergency that can be life or limb threatening, necessitating prompt and effective intervention to preserve limb function and patient survival. The standard treatment approaches include open thrombectomy, bypass surgery, and catheter-directed thrombolysis. Despite aggressive revascularisation, the reported 30-day amputation rate ranges between 8-30%, with an average length of stay of 11 days (SD9). Recent advancements in endovascular techniques have introduced the Lightning Bolt 7 device, a new device utilizing computer-aided mechanisms for rapid clot removal through modulated aspiration. This study aims to evaluate the efficacy and safety of the Lightning Bolt 7 device as a treatment for ALI. Method: A retrospective review from November 2023 to July 2024 was conducted to identify patients who presented with ALI and underwent treatment with the Lightning Bolt 7 at Flinders Medical Centre. Patient demographic and outcome data were collected. Results: A total of 12 patients were identified, with an average age was 68.5 years (SD 11.7), 67% were male and 33% female. Rutherford classification was 1 in 3 patients, 2a in 6 patients and 2b in 3 patients. Anatomically, 3/12 (25%) were treated for aorto-iliac pathology while the remainder (9/12) were infra-inguinal. Intra-operatively, alteplase was used to augment Lightning Bolt 7 in 3/12 (25%), while 1/12 (8%) required subsequent open thrombectomy due to the presence of refractory thrombus. There were no device related complications. At 30 days, all-cause mortality was 1/12 (8%) and 11/12 (92%) patients had limb salvage. The median length of stay was 3.5 days (IQR 3-6.5). Conclusion: Our early experience with Lightning Bolt 7 demonstrates that it is safe and effective for the treatment of ALI with high rates of limb salvage and the capacity to facilitate early discharge from hospital.