Abstract: Background: Warfarin is recognized as one of the most widely used drug for the therapeutic and prophylactic regimens for thromboembolic events in patients suffering from various cardiovascular disorders. Aim and Objectives: The aim of this study was to explore the experiences of patients regarding the OPD based warfarin monitoring. Materials and Methods: The phenomenological research design with purposive sampling technique was used to interview thirty patients on oral warfarin therapy who were attending (CTVS) OPDs. The data was analyzed by using Colaizzi’s method. Results: A total of eight core themes and twenty-nine sub-themes emerged from the data. It was found that despite their initial fear and worry, most of the participants were found to be accepting towards the initiation of warfarin therapy. The most common side effects which they suffered included bleeding and bruising. Although the patients reported satisfaction from the treatment facilities of the hospital, most of them reported facing much inconvenience due to frequent OPD visits. They expressed suffering from financial and psychological issues, a lack of knowledge regarding warfarin therapy and their quality of life also seemed to be impaired. Conclusion: It was concluded that long-term warfarin therapy significantly affects the quality of life of patients and careful monitoring of this drug is essential for successful treatment. Additionally, a need was found to provide detailed knowledge to the patients regarding care related to warfarin therapy that could somewhat assist in the prevention of their hospital visits for minor issues. Limitations: This is a single centre study. Conflict of Interest: None. Key words: Oral warfarin therapy, International Normalized Ratio, Quality of life, Knowledge, Out-patient department.