Introduction The NovoSorb® Biodegradable Temporising Matrix (BTM) is a synthetic polyurethane dermal matrix which facilitates the organisation of a neodermis. It has been used to reconstruct complex wounds and is well described in the management of burn injuries. There is limited evidence in vulnerable populations such as diabetic, ischaemic foot or groin wounds. Aims We present a single centre experience of BTM applied to six wounds to six adult patients at our institution in an 18-month period and the results of their wound healing. Methods Five patients with non-healing foot wounds were assessed for the perfusion, infection and shape to ensure optimisation of the wound bed prior to application of BTM. The initial post-operative course was managed with close monitoring during the acute in-patient stay with interval photography. Follow-up occurred through either a high-risk foot multidisciplinary service or the vascular surgery out-patient clinic until complete wound closure. Results All patients who received BTM for foot wounds had a WIfI stage 3 or 4. Complete wound healing was observed in three patients over a six-month period. One patient received split skin-grafting after delamination of the neodermis. Two patients are currently being followed prospectively regarding their wound healing progress. Conclusion BTM has been demonstrated to be a suitable alternative for wound management in the setting of chronic non-healing or infected wounds. There are many challenges with the use of BTM including labour-intensive resource requirements post-application and patient compliance. Prospective and multiple centre studies would aid in defining suitable candidates for this treatment.