Background: Pancreatic ductal adenocarcinoma (PDAC) often invades the lymphatic and neural tissue surrounding the superior mesenteric artery (SMA), which, if responsive to neoadjuvant chemotherapy, may then be surgically resected. Arterial resection/reconstruction, which has long been the technique of choice for treatment of peri-arterial disease, incurs increased morbidity, re-operation and mortality. Our multidisciplinary hepatopancreatobiliary and vascular surgery group thus describes a technique of arterial divestment to obviate SMA resection: periarterial neurolymphatic tissues infiltrated by tumour are carefully dissected from the arterial wall, achieving a non-infiltrated “sterile” arterial plane. Methods: We describe a technique of arterial divestment using a vascular stapler to shell the periadventitial tissue from the SMA en bloc, in patients without arterial invasion on intraoperative frozen section. We validate the safety of our technique by analysis of prospectively-collected surgical data of recipient patients (SPSS V23.0.0). Results: After detailing our unit’s technique, we present short- and long-term outcomes of 55 consecutive patients with a median follow up of 22 months: 42% had locally advanced and 51% borderline resectable PDAC. Median operative time was 480 minutes, median blood loss was 500mL and median postoperative hospital stay was 16 days. Major (Clavien-Dindo >3a) operative complications were experienced by 29.1%, with only 1 severe postoperative haemorrhage, and 1 perioperative mortality. R0 resection was achieved in 41.8% of cases. Median overall survival was 19mo (95% CI 13.2-24.8). Conclusions: If the arterial wall is unaffected by microscopic perineurial or lymphatic microscopic tumour spread following neoadjuvant therapy, arterial divestment can be safely performed, thereby allowing complete tumour clearance without SMA resection.